Analysis of novel cardiac biomarkers in diagnosis of decompensated heart failure

Abstract Aims Heart failure (HF) remains a major therapeutic and diagnostic challenge. In this study we aimed to analyze the predictive potential of four novel cardiovascular biomarkers – soluble urokinase-type plasminogen activator receptor (suPAR), vascular cell adhesion molecule (CAM-1), heart-type fatty acid binding Protein (H-FABP) growth/differentiation factor 15 (GDF-15) in detecting cardiac decompensation patients with HF. Methods total, 136 (40 decompensated HF, 96 compesated HF) were retrospectively enrolled serum biomarker concentrations GDF-15, suPAR, H-FABP CAM-1 analyzed by Enzyme Linked Immunosorbent Assay (ELISA). Biomarker correlated clinical biochemical parameters patients, value for was assessed ROC-plots, as well univariate multivariate logistic regression analysis. Cut-offs calculated means Youden index. Results A significant increase levels suPAR (1.6-fold change, p<0.0001), HFABP (2.2-fold p=0.0458) GDF-15 (1.7-fold p=0.0009) detected all HF compared compensated analysis, plasma H-FABP, significantly associated risk decompensation. For CAM-1, association remained even after correction confounders Additionally, AUCs (GDF-15: 0.759, 95% (0.683–0.866), suPAR: 0.838, (0.750–0.926), CAM-1: (0.750–0.926)) optimal cut-offs 1404.8835 pg/ml, 4774.027 4.74027 ng/ml) calculated. Correlation analyses found such creatinine inflammatory marker CRP be (r>0.3, p<0.001. conjunction results AUC NTproBNP (AUC=0.785), (AUC=0.838) (AUC=0.838 more accurately prediced heart than (Figure 1). Conclusion conclusion, investigated could valuable tool facilitate decisions suspicion Parameters renal function should taken into account. Funding Acknowledgement Type funding sources: None.